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Tensor encoding and decomposition of brain connectomes with application to tractography evaluation
Cesar Caiafa · Olaf Sporns · Andrew Saykin · Franco Pestilli

Thu Dec 07 12:15 PM -- 12:20 PM (PST) @ Hall A

Recently, linear formulations and convex optimization methods have been proposed to predict diffusion-weighted Magnetic Resonance Imaging (dMRI) data given estimates of brain connections generated using tractography algorithms. The size of the linear models comprising such methods grows with both dMRI data and connectome resolution, and can become very large when applied to modern data. In this paper, we introduce a method to encode dMRI signals and large connectomes, i.e., those that range from hundreds of thousands to millions of fascicles (bundles of neuronal axons), by using a sparse tensor decomposition. We show that this tensor decomposition accurately approximates the Linear Fascicle Evaluation (LiFE) model, one of the recently developed linear models. We provide a theoretical analysis of the accuracy of the sparse decomposed model, LiFE_SD, and demonstrate that it can reduce the size of the model significantly. Also, we develop algorithms to implement the optimization solver using the tensor representation in an efficient way.

Author Information

Cesar Caiafa (CONICET)
Olaf Sporns (Department of Psychological and Brain Sciences - Indiana University)
Andrew Saykin (IUPUI)
Franco Pestilli (Indiana University)

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