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Poster
Point process models for sequence detection in high-dimensional neural spike trains
Alex Williams · Anthony Degleris · Yixin Wang · Scott Linderman

Thu Dec 10 09:00 PM -- 11:00 PM (PST) @ Poster Session 6 #1827
in Poster Session 7 »

Sparse sequences of neural spikes are posited to underlie aspects of working memory, motor production, and learning. Discovering these sequences in an unsupervised manner is a longstanding problem in statistical neuroscience. Promising recent work utilized a convolutive nonnegative matrix factorization model to tackle this challenge. However, this model requires spike times to be discretized, utilizes a sub-optimal least-squares criterion, and does not provide uncertainty estimates for model predictions or estimated parameters. We address each of these shortcomings by developing a point process model that characterizes fine-scale sequences at the level of individual spikes and represents sequence occurrences as a small number of marked events in continuous time. This ultra-sparse representation of sequence events opens new possibilities for spike train modeling. For example, we introduce learnable time warping parameters to model sequences of varying duration, which have been experimentally observed in neural circuits. We demonstrate these advantages on recordings from songbird higher vocal center and rodent hippocampus.

Author Information

Alex Williams (Stanford University)
Anthony Degleris (Stanford University)
Yixin Wang (Columbia University)
Scott Linderman (Stanford University)

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