In this paper we introduce the MeanNN approach for estimation of main information theoretic measures such as differential entropy, mutual information and divergence. As opposed to other nonparametric approaches the MeanNN results in smooth differentiable functions of the data samples with clear geometrical interpretation. Then we apply the proposed estimators to the ICA problem and obtain a smooth expression for the mutual information that can be analytically optimized by gradient descent methods. The improved performance on the proposed ICA algorithm is demonstrated on standard tests in comparison with state-of-the-art techniques.