Inexpensive RGB-D cameras that give an RGB image together with depth data have become widely available. In this paper, we use this data to build 3D point clouds of full indoor scenes such as an office and address the task of semantic labeling of these 3D point clouds. We propose a graphical model that captures various features and contextual relations, including the local visual appearance and shape cues, object co-occurence relationships and geometric relationships. With a large number of object classes and relations, the model’s parsimony becomes important and we address that by using multiple types of edge potentials. The model admits efficient approximate inference, and we train it using a maximum-margin learning approach. In our experiments over a total of 52 3D scenes of homes and offices (composed from about 550 views, having 2495 segments labeled with 27 object classes), we get a performance of 84.06% in labeling 17 object classes for offices, and 73.38% in labeling 17 object classes for home scenes. Finally, we applied these algorithms successfully on a mobile robot for the task of finding objects in large cluttered rooms.