Abstract: While minwise hashing is promising for large-scale learning in massive binary data, the preprocessing cost is prohibitive as it requires applying (e.g.,) $k=500$ permutations on the data. The testing time is also expensive if a new data point (e.g., a new document or a new image) has not been processed. In this paper, we develop a simple \textbf{one permutation hashing} scheme to address this important issue. While it is true that the preprocessing step can be parallelized, it comes at the cost of additional hardware and implementation. Also, reducing $k$ permutations to just one would be much more \textbf{energy-efficient}, which might be an important perspective as minwise hashing is commonly deployed in the search industry. While the theoretical probability analysis is interesting, our experiments on similarity estimation and SVM \& logistic regression also confirm the theoretical results.