We present an agnostic active learning algorithm for any hypothesis class of bounded VC dimension under arbitrary data distributions. Most previous work on active learning either makes strong distributional assumptions, or else is computationally prohibitive. Our algorithm extends the simple scheme of Cohn, Atlas, and Ladner to the agnostic setting, using reductions to supervised learning that harness generalization bounds in a simple but subtle manner. We provide a fall-back guarantee that bounds the algorithm's label complexity by the agnostic PAC sample complexity. Our analysis yields asymptotic label complexity improvements for certain hypothesis classes and distributions. We also demonstrate improvements experimentally.