Recent advances in training deep learning algorithms have demonstrated potential to accommodate the complex variations present in medical data. In this talk, I will describe technical advancements and challenges in the development and clinical application of deep learning algorithms designed to interpret medical images. I will also describe advances and current challenges in the deployment of medical imaging deep learning algorithms into practice. This talk presents work that is jointly done with Matt Lungren, Curt Langlotz, Nigam Shah, and several more collaborators.