The research and development of new tools and strategies in the fight against malaria, already uses resources, data and computation spread across innumerable institutions and individuals. Whether this is towards an objective such as drug discovery or informing intervention policy, they present common requirements. Such threads may be interwoven to achieve common goals towards malaria eradication. This unifying influence may be the technology of Artificial Intelligence (AI), helping to tie together different efforts, necessitating Novel Exploration Techniques for scientific discovery and an Infrastructure for Research at Scale.