Climate change poses serious challenges to achieving food security in a time of a need to produce more food to keep up with the world’s increasing demand for food. There is an urgent need to speed up the development of new high yielding varieties with traits of adaptation and mitigation to climate change. Mathematical approaches, including ML approaches, have been used to search for such traits, leading to unprecedented results as some of the traits, including heat traits that have been long sought-for, have been found within a short period of time.