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Workshop Sat, Dec 6, 2025 • 8:00 AM – 5:00 PM PST

Biosecurity Safeguards for Generative AI

ZAIXI ZHANG ⋅ Amrit Singh Bedi ⋅ Mengdi Wang ⋅ Ruofan Jin ⋅ Le Cong ⋅ Souradip Chakraborty ⋅ Alvaro Velasquez
Project Page [ OpenReview] 

Video

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Schedule

Timezone: America/Los_Angeles
9:00 AM
Opening remarks
9:05 AM
Yoshua Bengio
9:35 AM
Peter Henderson
10:05 AM
Sheng Lin-Gibson
10:45 AM
Megan Blewett
11:15 AM
George Church
1:40 PM
Jian Ma
2:10 PM
Russ Altman
3:35 PM
Eric Xing
Without Safeguards, AI-Biology Integration Risks Creating Future Pandemics
Dianzhuo Wang ⋅ Marian Huot ⋅ Zechen Zhang ⋅ Kaiyi Jiang ⋅ Eugene Shakhnovich ⋅ Kevin Esvelt
Deep Research Brings Deeper Harm
Shuo Chen ⋅ Zonggen Li ⋅ Zhen Han ⋅ Bailan He ⋅ Tong Liu ⋅ Haokun Chen ⋅ Georg Groh ⋅ Philip Torr ⋅ Volker Tresp ⋅ Jindong Gu
RippleBench: Capturing Ripple Effects by Leveraging Existing Knowledge Repositories
Roy Rinberg ⋅ Usha Bhalla ⋅ Igor Shilov ⋅ Rohit Gandikota
SafeProtein: Red-Teaming Framework and Benchmark for Protein Foundation Models
Jigang Fan ⋅ Zhenghong Zhou ⋅ ZAIXI ZHANG ⋅ Ruofan Jin ⋅ Le Cong ⋅ Mengdi Wang
Prompting Toxicity: Analyzing Biosafety Risks in Genomic Language Models
Akshay Murthy ⋅ Mengmeng Zhang ⋅ Shanmukhi Kannamangalam ⋅ Benjamin Liu ⋅ Kevin Zhu
Benchmarking diffusion models for predicting perturbed cellular responses
Zijun Song ⋅ Changwen Zheng ⋅ Jiangmeng Li ⋅ Linhai Xie ⋅ Yujia Xiang
Translating Biomedical Observations into Signal Temporal Logic with LLMs using Structured Feedback
Hanna Krasowski ⋅ Lauren Malek ⋅ Sanjit Seshia ⋅ Murat Arcak
ABC-Bench: An Agentic Bio-Capabilities Benchmark for Biosecurity
Andrew Liu ⋅ Samira Nedungadi ⋅ Bryce Cai ⋅ Alex Kleinman ⋅ Harmon Bhasin ⋅ Seth Donoughe
Deep Ignorance: Filtering Pretraining Data Builds Tamper-Resistant Safeguards into Open-Weight LLMs
Kyle O'Brien ⋅ Stephen Casper ⋅ Quentin Anthony ⋅ Tomek Korbak ⋅ Robert Kirk ⋅ Xander Davies ⋅ Ishan Mishra ⋅ Geoffrey Irving ⋅ Yarin Gal ⋅ Stella Biderman
SafeGenie: Erasing Dangerous Concepts from Biological Diffusion Models
Arjun Banerjee ⋅ Ethan Tam ⋅ Camille Dang ⋅ David Martinez
Agentic BAIM-LLM Evaluation (ABLE): Benchmarking LLM Use of Protein Design Tools
Bryce Cai ⋅ Geetha Jeyapragasan ⋅ Samira Nedungadi ⋅ Jake Yukich ⋅ Seth Donoughe
Property Adherent Molecular Generation with Constrained Discrete Diffusion
Michael Cardei ⋅ Jacob K Christopher ⋅ Bhavya Kailkhura ⋅ Tom Hartvigsen ⋅ Ferdinando Fioretto
Zero-Shot Embedding Drift Detection: A Lightweight Defense Against Prompt Injections in LLMs
Arjun Damerla ⋅ Anirudh Sekar ⋅ Rachel Sharma ⋅ Mrinal Agarwal ⋅ Jasmine Zhang ⋅ Akitsugu Tanaka
Open-weight genome language model safeguards: Assessing robustness via adversarial fine-tuning
James Black ⋅ Moritz Sebastian Hanke ⋅ Aaron Maiwald ⋅ Tina Hernandez-Boussard ⋅ Oliver Crook ⋅ Jaspreet Pannu
Securing Dual-Use Pathogen Data of Concern
Doni Bloomfield ⋅ Moritz Sebastian Hanke ⋅ Aaron Maiwald ⋅ James Black ⋅ Toby Webster ⋅ Tina Hernandez-Boussard ⋅ Allison Berke ⋅ Oliver Crook ⋅ Jaspreet Pannu
Resisting RL Elicitation of Biosecurity Capabilities: Reasoning Models Exploration Hacking on WMDP
Joschka Braun ⋅ Yeonwoo Jang ⋅ Damon Falck ⋅ Roland S. Zimmermann ⋅ David Lindner ⋅ Scott Emmons
Benchmarking Mitigations Against Covert Misuse
Davis Brown ⋅ Mahdi Sabbaghi ⋅ Luze Sun ⋅ Alexander Robey ⋅ George J. Pappas ⋅ Eric Wong ⋅ Hamed Hassani
Is My Language Model a Biohazard?
Aldan Creo ⋅ Cristina Correa
Best Practices for Biorisk Evaluations on Open-Weight Bio-Foundation Models
Boyi Wei ⋅ Zora Che ⋅ Nathaniel Li ⋅ Jasper Götting ⋅ Samira Nedungadi ⋅ Julian Michael ⋅ Summer Yue ⋅ Dan Hendrycks ⋅ Peter Henderson ⋅ Zifan Wang ⋅ Seth Donoughe ⋅ Mantas Mazeika
Biorisk-Shift: Converting AI Vulnerabilities into Biological Threat Vectors
Eun Ro ⋅ Yoshi Nakachi ⋅ Yang Chung ⋅ Steven Basart
Where to Edit? : Complementary Protein Property Control from Weight and Activation Spaces
Armaity Katki ⋅ Nathan Choi ⋅ Son Otra ⋅ George Flint ⋅ Kevin Zhu
GeneBreaker: Jailbreak Attacks against DNA Language Models with Pathogenicity Guidance
ZAIXI ZHANG ⋅ Zhenghong Zhou ⋅ Ruofan Jin ⋅ Le Cong ⋅ Mengdi Wang
Involuntary Jailbreak
Yangyang Guo ⋅ Yangyan Li ⋅ Mohan Kankanhalli
Monte Carlo Expected Threat (MOCET) Scoring
Joseph Kim ⋅ Saahith Potluri
Robust LLM Unlearning with MUDMAN: Meta-Unlearning with Disruption Masking And Normalization
Filip Sondej ⋅ Yushi Yang ⋅ Mikolaj Kniejski ⋅ Marcel Windys