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Workshop: Machine Learning in Structural Biology Workshop

What is hidden in the darkness? Characterization of AlphaFold structural space

Janani Durairaj · Joana Maria Soa Pereira · Mehmet Akdel · Torsten Schwede


The recent public release of the latest version of the AlphaFold database has given us access to over 200 million predicted protein structures. We use a "shape-mer" approach, a structural fragmentation method analogous to sequence k-mers, to describe these structures and look for novelties - both in terms of proteins with rare or novel structural composition and possible functional annotation of under-studied proteins.

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